eld.gg Path of Exile 2 Currency: Bring Bleed removal

Path of Exile 2: All Anomaly Bosses and How to Clear Them

Anomaly bosses in Path of Exile 2 have quickly become some of the most challenging and rewarding encounters in the game. Introduced in patch 0.3, these bosses drop exclusive Lineage Support Gems that are highly sought after for endgame builds. As of now, there are four Anomaly bosses, all tied to final encounters from Act 4 and the three Interludes. This guide covers all Anomaly bosses, how to locate them, strategies to defeat them, and the unique rewards you can earn.

Vaal Interlude – Recruit the Vaal

The final Interlude sends players into the remains of the Vaal Empire, uncovering Doryani’s hidden contingency plan.

Permanent upgrades include:

+40 Spirit for defeating Lythara in Kriar Village
+2 Passive Skill Points for defeating the Abominable Yeti in the Howling Caves

These bonuses are especially valuable for minion, aura, and Spirit-heavy builds.

General Tips for Surviving Atziri (0.4.0)

Movement is your best defense. Atziri’s telegraphs are readable, but damage is extremely serious.
Don’t overheal her during the Add Phase. Missing ads is the most common cause of failed attempts.
Avoid reflected clones at all costs. One mistaken hit can instantly kill you.
Use defensive Flasks intelligently. POE2’s Flask system rewards timing over spam.
Bring Bleed removal. Her spear barrage inflicts heavy bleeds.
Don’t get greedy on DPS. Most deaths come from staying in too long during Flameblast or Storm Call.

Final Thoughts

Act 4 in Path of Exile 2 rewards exploration and smart routing. While the open-ended structure can feel overwhelming, completing optional islands early provides major power spikes that smooth out the rest of the campaign. By following an optimized island order and fully clearing the Interludes, you’ll enter the Atlas endgame with stronger defenses, more skill points, and better overall build flexibility.

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